In November 1849, Dr. George Parkman, one of Boston's richest citizens, suddenly disappeared. The police conducted an extensive search of the city and dredged the Charles River. Parkman had last been seen walking towards the Harvard Medical College. The Medical School's janitor, Ephraim Littlefield, who had a suspicion where Parkman might be found, spent two grueling nights tunneling beneath a basement laboratory looking for clues. What he discovered horrified Boston and led to one of the most sensational trials in American history.